Biological analyses

Global miRNA analysis

In this cooperation with scientists from the German Cancer Research Center (DKFZ, Heidelberg) we contributed a new method to analyse noisy biological high-throughput data. In this case, Özgür et al. were interested in the influence of so-called microRNAs on the level of certain proteins. These proteins regulate the cell cycle in a very malicious breast cancer type. Since microRNA regulation is in general very mild, it is difficult to decide whether a given change in a protein's level is for real or just a random fluctuation. We attacked this problem by assessing the statistical significance of co-regulations, i.e., we checked whether pairs of proteins where significantly often co-regulated by microRNAs.

Selected Publications

Press Coverage