Global miRNA analysisIn this cooperation with scientists from the German Cancer Research Center (DKFZ, Heidelberg) we contributed a new method to analyse noisy biological high-throughput data. In this case, Özgür et al. were interested in the influence of so-called microRNAs on the level of certain proteins. These proteins regulate the cell cycle in a very malicious breast cancer type. Since microRNA regulation is in general very mild, it is difficult to decide whether a given change in a protein's level is for real or just a random fluctuation. We attacked this problem by assessing the statistical significance of co-regulations, i.e., we checked whether pairs of proteins where significantly often co-regulated by microRNAs.
- Stefan Uhlmann, Heiko Mannsperger, Jitao David Zhang, Emöke-Ágnes Horvát, Christian Schmidt, Moritz Küblbeck, Frauke Henjes, Aoife Ward, Ulrich Tschulena, Katharina Zweig, Ulrike Korf, Stefan Wiemann, and Özgür Sahin: "Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer", Molecular Systems Biology 8:569, doi: 10.1038/msb.2012.2, 2012
- The article was featured on nature.com and accompanied by a 'news and views' article by Marcos Malumbres
- Press release of the Heidelberg university
- Nationales Genomforschungsnetzwerk